Structural Biology 🔬

Inspirational Works

Accurate structure prediction of biomolecular interactions with AlphaFold 3

Accurate structure prediction of biomolecular interactions with AlphaFold 3
Abramson, Adler, Dunger, et al.
Nature, 630, 493–500 (2024)

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Structure, function and pharmacology of human itch GPCRs

Structure, function and pharmacology of human itch GPCRs
Cao, Kang, Singh, et al.
Nature, 600, 170–175 (2021)

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Highly accurate protein structure prediction with AlphaFold

Highly accurate protein structure prediction with AlphaFold
Jumper, Evans, Pritzel, et al.
Nature, 596, 583–589 (2021)

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CryoDRGN-AI: neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets

CryoDRGN-AI: neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets
Levy, Raghu, Feathers, et al.
Nat Methods, 22, 1486–1494 (2025)

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Cryo-EM structure of a type IV secretion system

Cryo-EM structure of a type IV secretion system
Macé, Vadakkepat, Redzej, et al.
Nature, 607, 191–196 (2022)

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Single-particle cryo-EM at atomic resolution

Single-particle cryo-EM at atomic resolution
Nakane, Kotecha, Sente, et al.
Nature, 587, 152–156 (2020)

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Bridging structural and cell biology with cryo-electron microscopy

Bridging structural and cell biology with cryo-electron microscopy
Nogales, Mahamid
Nature, 628, 47–56 (2024)

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Learning structural heterogeneity from cryo-electron sub-tomograms with tomoDRGN

Learning structural heterogeneity from cryo-electron sub-tomograms with tomoDRGN
Powell, Davis
Nat Methods, 21, 1525–1536 (2024)

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CryoDRGN-ET: deep reconstructing generative networks for visualizing dynamic biomolecules inside cells

CryoDRGN-ET: deep reconstructing generative networks for visualizing dynamic biomolecules inside cells
Rangan, Feathers, Khavnekar, et al.
Nat Methods, 21, 1537–1545 (2024)

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AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination
Terwilliger, Liebschner, Croll, et al.
Nat Methods, 21, 110–116 (2024)

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Highly accurate protein structure prediction for the human proteome

Highly accurate protein structure prediction for the human proteome
Tunyasuvunakool, Adler, Wu, et al.
Nature, 596, 590–596 (2021)

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Structural pharmacology and therapeutic potential of 5-methoxytryptamines

Structural pharmacology and therapeutic potential of 5-methoxytryptamines
Warren, Lankri, Cunningham, et al.
Nature, 630, 237–246 (2024)

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Predicting multiple conformations via sequence clustering and AlphaFold2

Predicting multiple conformations via sequence clustering and AlphaFold2
Wayment-Steele, Ojoawo, Otten, et al.
Nature, 625, 832–839 (2024)

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Structure, function and pharmacology of human itch receptor complexes

Structure, function and pharmacology of human itch receptor complexes
Yang, Guo, Li, et al.
Nature, 600, 164–169 (2021)

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Atomic-resolution protein structure determination by cryo-EM

Atomic-resolution protein structure determination by cryo-EM
Yip, Fischer, Paknia, et al.
Nature, 587, 157–161 (2020)

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Ligand efficacy modulates conformational dynamics of the µ-opioid receptor

Ligand efficacy modulates conformational dynamics of the µ-opioid receptor
Zhao, Elgeti, O'Brien, et al.
Nature, 629, 474–480 (2024)

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CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks

CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks
Zhong, Bepler, Berger, et al.
Nat Methods, 18, 176–185 (2021)

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The structural basis of odorant recognition in insect olfactory receptors

The structural basis of odorant recognition in insect olfactory receptors
del Mármol, Yedlin, Ruta
Nature, 597, 126–131 (2021)

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