Pharmacology 🔬

https://toxicology.substack.com/

Inspirational Works

Structure, function and pharmacology of human itch GPCRs

Structure, function and pharmacology of human itch GPCRs
Cao, Kang, Singh, et al.
Nature, 600, 170–175 (2021)

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Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases

Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases
Co, Margalef-Català, Monack, Amieva
Nat Protoc, 16, 5171–5192 (2021)

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Meta-analysis and the science of research synthesis

Meta-analysis and the science of research synthesis
Gurevitch, Koricheva, Nakagawa, et al.
Nature, 555, 175–182 (2018)

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Systematic review and meta-analysis of preclinical studies

Systematic review and meta-analysis of preclinical studies
Ineichen, Held, Salanti, et al.
Nat Rev Methods Primers, 4, 72 (2024)

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Human disease models in drug development

Human disease models in drug development
Loewa, Feng, Hedtrich
Nat Rev Bioeng, 1, 545–559 (2023)

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Unlocking the potential of disease prevention through regulatory science

Unlocking the potential of disease prevention through regulatory science
Nature Editorial
Nature (2026)

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Intestinal organoid cocultures with microbes

Intestinal organoid cocultures with microbes
Puschhof, Pleguezuelos-Manzano, Martinez-Silgado, et al.
Nat Protoc, 16, 4633–4649 (2021)

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A comprehensive map of molecular drug targets

A comprehensive map of molecular drug targets
Santos, Ursu, Gaulton, et al.
Nat Rev Drug Discov, 16, 19–34 (2017)

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Structural pharmacology and therapeutic potential of 5-methoxytryptamines

Structural pharmacology and therapeutic potential of 5-methoxytryptamines
Warren, Lankri, Cunningham, et al.
Nature, 630, 237–246 (2024)

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Structure, function and pharmacology of human itch receptor complexes

Structure, function and pharmacology of human itch receptor complexes
Yang, Guo, Li, et al.
Nature, 600, 164–169 (2021)

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Ligand efficacy modulates conformational dynamics of the µ-opioid receptor

Ligand efficacy modulates conformational dynamics of the µ-opioid receptor
Zhao, Elgeti, O'Brien, et al.
Nature, 629, 474–480 (2024)

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The structural basis of odorant recognition in insect olfactory receptors

The structural basis of odorant recognition in insect olfactory receptors
del Mármol, Yedlin, Ruta
Nature, 597, 126–131 (2021)

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Lab Publications

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Discussion